Work Package 3

Title of Work Package: Molecular biomarkers for disease progression and monitoring therapy

Objectives: WP3 will concentrate on discovery and validation of biomarkers to monitor disease progression and therapeutic effects. We will use biomaterial from patients available through our registry (WP1) and our clinical study (WP4). Blood samples will be collected at intervals for RNA extraction and serum preparation. Biomaterials (including blood, serum, urine and tissues) derived from animal models will be also used to establish transcriptomic and metabolomic profiles under basal conditions and to monitor the effects of treatments as described in WP5.


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